ISBN 9780199545063,Aging Of The Genome

Aging Of The Genome

Author:

Jan Vijg

Publisher:

OUP India

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ISBN 9780199545063
Publisher

OUP India

Publication Year 2008
ISBN-13

ISBN 9780199545063

ISBN-10 0199545065
Binding

Paper Back

Number of Pages 384 Pages
Language (English)
Subject

Educational: Biology

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

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