A type of cancer that occurs in the cells that form bones is referred to as osteosarcoma. It is caused when the cells that are responsible for the formation of bones develop changes in their DNA. The signs and symptoms of osteosarcoma are swelling near a bone, bone or joint pain, and bone injury or fracture without any reason. Osteosarcoma can be diagnosed by X-ray, computerized tomography, magnetic resonance imaging, positron emission tomography, bone scan, needle biopsy, and surgical biopsy. It can be treated through chemotherapy, radiation therapy, and surgeries such as amputation, rotationplasty, and limb-sparing surgery. The topics included in this book on osteosarcoma are of utmost significance and bound to provide incredible insights to readers. Also included herein is a detailed explanation of the various concepts and researches on osteosarcoma. Scientists and students actively engaged in this field will find this book full of crucial and unexplored concepts.