Jones And Bartlett Publishers

Publication Year 2014

ISBN 9789380853710

ISBN-10 9380853718


Number of Pages 968 Pages
Language (English)


Molecular Biology is a rapidly advancing field with a constant flow of new information and cutting-edge developments that impact our lives. Lewin's GENES has long been the essential resource for providing the teaching community with the most modern presentation to this dynamic area of study. Lewin"s GENES XI continues this tradition by introducing the most current data from the field, covering gene structure, sequencing, organization, and expression. A wealth of subject-matter experts, from top institutions, to provide content updates and revisions in their individual areas of study. A reorganized chapter presentation provides a clear, more student-friendly introduction to course material than ever before.

New and Key Features of Lewin"s GENES XI:

Updated content throughout to keep pace with this fast-paced field
Reorganized chapter presentation provides a clear, student-friendly introduction to course material
Expanded coverage describing the connection between replication and the cell cycle is included, and presents eukaryotes as well as prokaryotes
A wealth of pedagogical features throughout the text help student to understand better and retain important data.
About the Author
Jocelyn E. Krebs has been a member of the Department of Biological Sciences at the University of Alaska Anchorage since 2000. She received her B.A. in Biological Sciences from Bard College in 1991 and her PhD in Molecular and Cell Biology from the University of California Berkeley in 1997. Her research focuses on the mechanisms by which DNA transactions such as transcription and repair are accomplished in the context of chromatin. Her teaching interests are in Molecular Biology (taught at the undergraduate, graduate, and first-year medical school levels), as well as the Molecular Biology of Cancer.

Stephen T. Kilpatrick is an Associate Professor of Biology at the University of Pittsburgh at Johnstown (UPJ). He received a B.S. in Biology for Eastern College (now Eastern University) and a PhD from the Program in Ecology and Evolutionary Biology at Brown University. His research an teaching interests are in evolutionary molecular genetics. UPJ is an undergraduate degree-granting campus of the University of Pittsburgh, and

Dr. Kilpatrick regularly teaches undergraduate courses in majors introductory biology, genetics, evolution, molecular genetics, and biostatistics. Prior to coauthoring the Second Edition of Lewin's Essential Genes, Dr. Kilpatrick has co-authored the test banks for the first edition and for Lewin's GENES VIII and GENES IX. He has also authored ancillaries and pedagogical materials for several introductory non-majors and majors biology and genetics textbooks.

Elliott S. Goldstein earned his B.S. in Biology from the University of Hartford (Connecticut) and his Ph.D. in Genetics from the University of Minnesota, Department of Genetics and Cell Biology. Following this, he was awarded an N.I.H. Postdoctoral Fellowship to work with Dr. Sheldon Penman at the Massachusetts Institute of Technology. Leaving Boston, he joined the faculty at Arizona State University in Tempe, where he is an Associate Professor in the Cellular, Molecular and Biosciences program in the School of Life Sciences, and in the Honors Disciplinary Program. His research interests are in the area of molecular and developmental genetics of early embryogenesis in Drosophila melanogaster. In recent years, he has focused on the Drosophila counterparts of the human proto-oncogenes jun and fos. His primary teaching responsibilities are in the undergraduate General Genetics course as well as the graduate level Molecular Genetics course.

Table of Contents

Part 1: Genes and Chromosomes

Chapter 1: Genes Are DNA
Chapter 2: Genes Encode RNAs and Polypeptides
Chapter 3: Methods in Molecular Biology and Genetic Engineering
Chapter 4: The Interrupted Gene
Chapter 5: The Content of the Genome
Chapter 6: Genome Sequences and Gene Numbers
Chapter 7: Clusters and Repeats
Chapter 8: Genome Evolution
Chapter 9: Chromosomes
Chapter 10: Chromatin

Part 2: DNA Replication and Recombination

Chapter 11: Replication Is Connected to the Cell Cycle
Chapter 12: The Replicon: Initiation of Replication
Chapter 13: DNA Replication
Chapter 14: Extrachromosomal Replicons
Chapter 15: Homologous and Site-Specific Recombination
Chapter 16: Repair Systems
Chapter 17: Transposable Elements and Retroviruses
Chapter 18: Somatic Recombination and Hypermutationin the Immune System

Part 3: Transcription and Posttranscriptional Mechanisms

Chapter 19: Prokaryotic Transcription
Chapter 20: Eukaryotic Transcription
Chapter 21: RNA Splicing and Processing
Chapter 22: mRNA Stability and Localization
Chapter 23: Catalytic RNA
Chapter 24: Translation
Chapter 25: Using the Genetic Code

Part 4: Gene Regulation

Chapter 26: The Operon
Chapter 27: Phage Strategies
Chapter 28: Eukaryotic Transcription Regulation
Chapter 29: Epigenetic Effects Are Inherited
Chapter 30: Regulatory RNA

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