ISBN 9780195674170,Organic Synthesis

Organic Synthesis



Oxford University Press

Publication Year 2005

ISBN 9780195674170

ISBN-10 0195674170


Number of Pages 96 Pages
Language (English)


This valuable text uses a wide range of examples to teach students of chemistry how to adopt a logical and versatile approach to the design of synthetic routes.

The concept of retrosynthetic analysis - a means for identifying simple starting materials for a synthesis - is first introduced with emphasis on the importance of bond polarity and functional group interconversions. The next section describes how an effective route to a target molecule containing more than one functional group can be elucidated, and gives useful strategies to adopt when designing syntheses. Later chapters review methods for the control of chemo-, regio-, and stereoselectivity, and include a discussion of protecting groups. Finally, four syntheses of the pyrrolidine alkaloids are compared and contrasted using the principles described in the book. Practice examples are provided throughout, making this concise text an invaluable study aid for all undergraduate chemists.

Key Features
Provides a logical, structured introduction to the principles of retrosynthetic analysis
The only concise text on synthesis at this level
Includes a table of common synthons
Lists guidelines for efficient synthesis design
Includes practice examples throughout the book

About The Author
K. J. Willis School of Geography and the Environment, University of Oxford
Martin Wills Reader in Organic Chemistry, University of Warwick

Table Of Contents
Introduction to synthesis
Retrosynthetic analysis I: The basic concepts
Retrosynthetic analysis II: Latent polarity and FGIs
Retrosynthetic analysis III: Strategy and planning in synthesis
Selectivity I: Chemoselectivity and protecting groups 6
Chemoselectivity II: Regioselectivity
Chemoselectivity III: Stereoselectivity
Selected organic synthesis
Appendix: Synthon table

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