It provides holistic understanding of real-life clinical situations by integrating the basic principles of pharmacology with clinical use of drugs. It includes a broader coverage of topics of pharmacology having clinical relevance, and each topic has been dealt in-depth to strengthen the concepts and makes learning more effective. Hypothetical case scenarios are designed and the principles of pharmacology in drug use is discussed in a question-answer format progressing stepwise from the basics to higher learning levels of each topic. The book will be beneficial for different categories of learners—poor, medium and advanced. There is greater emphasis on 'rationale type' questions to improve reasoning and analytical skills of the learner. Schematic diagrams, flowcharts and tables have been included wherever necessary to improve understanding and makes learning more effective. The book includes difficult to understand topics such as antiarrhythmics, heart failure, antiepileptics, antidepressants, antipsychotics' general anesthetics, etc. Recent changes in treatment guidelines as in tuberculosis, epilepsy, hypertension and diabetes, have been taken into account while explaining therapeutic use of drugs. List of resources (i.e. references, books) for further reading has been given at the end of each chapter. This will provide authenticity to the content and instill confidence in the minds of the readers. Structure and content of this book is unique and makes learning effective and interesting