A major national goal is to improve our health and advance our opportunities to pursue happiness. Simulta­ neously, there are increasing health care costs and increasing demands to accomplish more with less financial support. Treatment costs can be reduced and health improved by preventing the toxic effects of drugs. This first volume of our new series, Drug and Alcohol to reduce the use and Abuse Reviews, focuses on stategies abuse of common compounds known to cause major damage to health: alcohol, tobacco, and illicit drugs such as cocaine and heroin