Sarcoma is a kind of cancer that can occur in several locations in the human body. It generally begins in the bones or in the soft tissues such as muscles, fat, blood vessels, nerves, and tendons. There are nearly 70 types of sarcoma. It develops due to mutations in the DNA of the cells. A few of the signs and symptoms of sarcoma are a lump that can be felt through the skin, bone pain, an unexpected bone fracture, abdominal pain, and weight loss. The tests and procedures used to diagnose sarcoma and determine its stage are X-rays, physical exam, MRI, CT scan, bone scan, PET scans, ultrasound, and biopsy. It can be treated with surgery that aims to remove all the cancer cells. Other possible treatments are radiation therapy, chemotherapy, immunotherapy, ablation therapy, and targeted drug therapy. This book discusses the fundamentals as well as modern approaches to clinical research in sarcoma. It presents researches and studies performed by experts across the globe. This book will provide comprehensive knowledge to the readers.