The new edition is prepared as per the competency based medical education (cbme) MBBS curriculum and the content of the book is modified from the traditional organism-based teaching to system-based. This is the only practical textbook in “clinical microbiology” based on infective syndromes and written in class-wise pattern according to undergraduate practical schedule. It helps teacher to teach during a practical class, what to keep for demonstration during the practical class and gives teacher a holistic approach to make the yearly practical schedule.