The Serpent's wave of terror has targeted Namor's underwater kingdom. Down but not out, the Sub-Mariner calls upon old friend Dr. Strange for help. And backed by a team of allies including the Silver Surfer and the Savage She-Hulk Lyra, he means to take back what is his! Meanwhile, the shockwave of fear hits the surface world. Believing the coming destruction as a sign from God, the mutant-hating Purifiers launch an attack of their own - engineering the mass suicide of innocent humans. Wolverine and the black-ops squad X-Force aim to find out who's responsible for the suicide epidemic.