At the centre of Nemesis is a vigorous, dutiful, twenty-three-year old playground director, Bucky Cantor, a javelin thrower and a weightlifter, who is devoted to his charges and disappointed with himself because his weak eyes have excluded him from serving in the war alongside his contemporaries. Focusing on Cantor's dilemmas as polio begins to ravage his playground - and on the everyday realities he faces - Roth leads us through every inch of emotion such a pestilence can breed: the fear, the panic, the anger, the bewilderment, the suffering, and the pain.