This book is designed to give you an insight of the art and science of Computers. The book does not need any special background to comprehend the subject matter. The book covers the entire course contents of Computer Science with Python Language in a clear and simple English language. It discusses Programming and Computational Thinking, Computer Systems and Organisation Concepts in very comprehensive manner to build a strong foundation. The Programming methodology and Introduction to Python language are described in easy-to-understand language. Different topics such as Control structures, Strings, Lists, Dictionaries and Tuples are explained in a very easy to understand language.