ICH Guidelines on Thalassemia 2025 is a national, evidence-based clinical guideline from the Indian College of Hematology under the Indian Society of Hematology and Blood Transfusion (ISHBT). It offers quality, evidence-based recommendations for clinicians and health professionals working on the prevention, diagnosis and management of thalassemia in India, with an explicit emphasis on multidisciplinary care across specialties. Twenty authored chapters cover the epidemiology and burden of thalassemia, laboratory, molecular and prenatal diagnosis, community-level screening relevant to the national program, thalassemia syndromes and clinical features, blood transfusion, iron overload diagnosis and chelation, patient monitoring, and management of complications. Further chapters address evaluation of cardiac status, endocrine evaluation, imaging, hematopoietic stem cell transplant for thalassemia major, fetal hemoglobin induction in beta-thalassemia, psychological support for patients and parents, recent advances, the role of NGOs and corporates, and translational research. The text is written in a concise, recommendation-led format supported by summary tables and flowcharts, including a staged screening and confirmation strategy mapped to each level of the healthcare system. Who This Book Is For: Hematologists: as a working reference for diagnosis, transfusion planning, iron chelation and long-term monitoring of patients with thalassemia. Pathologists and pediatricians: for laboratory and molecular diagnosis, carrier screening, prenatal diagnosis and coordinated care of children with transfusion-dependent thalassemia. Why This Book Helps: One national reference: consolidates prevention, diagnosis, treatment and monitoring of thalassemia into a single evidence-based document for Indian practice. Supports multidisciplinary care: brings transfusion, cardiology, endocrinology, imaging, transplant and psychological input together around the thalassemia patient. Strengthens screening programs: provides a practical, healthcare-level-wise screening and confirmation pathway relevant to the national program. Guides iron-overload management: structures diagnosis and chelation of iron overload and the monitoring of end-organ effects. Covers newer options: includes stem cell transplant, fetal hemoglobin induction and recent advances to inform referral decisions. Key Features: 20 authored chapters spanning epidemiology, diagnosis, transfusion, iron chelation, complications and translational research. Staged screening and confirmation strategy mapped to each level of the healthcare system, with a summary table and flowchart. Dedicated chapters on cardiac status evaluation, endocrine evaluation and imaging in thalassemia. Chapter on hematopoietic stem cell transplant for thalassemia major and a chapter on fetal hemoglobin induction in beta-thalassemia. Guidance on prenatal and molecular diagnosis and on community-level carrier screening for the national program.