Unlike other science books, this definitive guide to immunotherapies including vaccines and vaccinology is expressed in an open-minded, persuasive narrative style. The book chapters start with a historical overview of vaccination, highlighting key milestones and breakthroughs in the field. The book opens with a historical account, tracing the advancements in vaccination and introducing the pioneers of vaccine discovery. It aims to give readers a clear understanding of the progression of immunization practices and to spark thoughts on the future directions in this vital area of science. This Vaccinology Book 2024, with its colorful text and illustrations, explains the immunization history and benefits of saving humans from the world's pandemics. • Our book, World of Vaccinology 2024, is a multidisciplinary scientific initiative dedicated to understanding the evolving cellular and molecular biology of vaccines within bio- and regenerative medicine • The book’s primary focus is to explain its relevance to vaccinology and immunotherapy. Summarize the vaccine development and immunotherapy advancements discussed in the book, including new therapeutic strategies and technological innovations • Recent breakthroughs in vaccination have illuminated the therapeutic applications of vaccines for a broader array of cancers and immunologically mediated, noncommunicable diseases (NCDs), revealing new possibilities in disease prevention and treatment • The book reviews the evolution of immunotherapies from early bacterial approaches like Bacillus Calmette–Guérin (BCG) therapy for bladder cancer to modern prophylactic and therapeutic vaccines • Building on the success of mRNA vaccines for infectious diseases, this book explores their potential in cancer nanomedicine and highlights recent immunotherapy advances and their future prospects