Insulin is a hormone produced by the pancreas to help the body use glucose for energy. When the cells in the muscles, fat, and liver don't respond well to insulin and are unable to use glucose from the blood for energy, it is termed as insulin resistance. Insulin resistance is associated with diabetes, hypertension, dyslipidemia, cardiovascular disease, and other abnormalities. These abnormalities constitute insulin resistance syndrome. It can be diagnosed by evaluating the family's medical history, physical exam, and blood tests such as fasting plasma glucose test, oral glucose tolerance test, and hemoglobin A1c test. Insulin resistance can be treated by medications, regular exercise, a healthy diet, and maintaining a healthy weight. This book discusses the fundamentals as well as modern approaches to insulin resistance. It presents researches and studies performed by experts across the globe. This book will provide comprehensive knowledge to the readers.