Insulin resistance (IR) is a condition where cells in the muscles, fat and liver do not respond to insulin and are unable to utilize glucose from the blood for energy. As a response, the pancreas creates more insulin, and over time, the blood sugar levels increase, which can lead to diabetes. IR syndrome leads to problems such as obesity, high blood pressure, high cholesterol and type 2 diabetes. A blood test can be used to check the blood sugar levels to diagnose this condition. Factors like obesity, a sedentary lifestyle, various health conditions, certain medications and a family history of diabetes can increase the chances of suffering from IR. Lifestyle changes like exercise and a healthy diet may be able to manage this condition. This book discusses the fundamentals of, as well as modern approaches to the treatment of insulin resistance. It presents researches and studies performed by experts across the globe. This book is an essential guide for both academicians and those who wish to pursue this discipline further.