The abnormal enlargement or thickening of the heart muscle resulting from increases in cardiomyocyte size and changes in other heart muscle components such as extracellular matrix is referred to as cardiac hypertrophy. It can be caused by gene mutation, excessive exercise, hypertension or valvular disease. Cardiac hypertrophy shows symptoms such as chest pain, fainting, shortness of breath and palpitations. It can be diagnosed by echocardiogram, electrocardiogram and cardiac MRI. Cardiac hypertrophy can be treated through septal myectomy, septal ablation, implantable cardioverter-defibrillator and medications such as beta-blockers, calcium channel blockers, heart rhythm drugs and blood thinners. This book elucidates the concepts and innovative models around prospective developments with respect to cardiac hypertrophy research. Different approaches, evaluations, methodologies, and advanced studies on the topic have been included in this book. Scientists and students actively engaged in research of cardiac hypertrophy will find this book full of crucial and unexplored concepts.